|
KMID : 0356820090250020128
|
|
Korean Journal of Head & Neck Oncology
2009 Volume.25 No. 2 p.128 ~ p.131
|
|
|
Clinical Manifestation and Treatment Results of the Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Arising in the Head and Neck Region
|
|
Rah Yoon-Chan
Han Kyu-Hee
An Soo-Youn
Kwon Tack-Kyun
Sung Myung-Whun
Kim Kwang-Hyun
Hah Jeong-Hun
|
|
|
Abstract
|
|
|
Objectives : Mucosa-associated lymphoid tissue(MALT) lymphoma of the head and neck region is relatively rare, but it has variable clinical and biological characteristics. Although there were few studies on this topic, there is still controversy regarding the best treatment. The authors retrospectively investigated the clinical courses and treatment results in 10 patients presenting with MALT-lymphoma in head and neck region except ocular adnexa.
Material and Methods : Ten patients with a histologically verified diagnosis of the extranodal marginal zone B cell lymphoma arising in thyroid glands(3), larynx(3), oral cavity(2), oropharynx(1), salivary glands(1) were analyzed.
Results : Four patients were allocated to stage IE and another six patients to stage IIE according to the Ann Arbor staging system. Treatment consisted of local therapy(surgical resection and/or radiotherapy) in four patients and systemic chemotherapy with/without local therapy in six patients. Complete remission and partial remission were achieved in seven patients(70%) and two patients(20%), respectively. No recurrence or mortality was observed with a mean follow-up of 40.5 months.
Conclusion : Patients with MALT-lymphomas of the head and neck region were potentially treated by local modality in localized disease state. However systemic chemotherapy was also effective even in localized disease state and was well tolerated by patients. And strict staging and close long-term monitoring were recommended considering its indolent progression.
|
|
|
KEYWORD
|
|
|
MALT lymphoma, Extranodal marginal zone B-cell lymphoma, Head and neck neoplasm
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|